Product Overview
Recombinant Human IL-3 is a single non-glycosylatedpolypeptide chain containing 133 amino acids and having a molecular weight of15,000 Da. The sequence of the first five N-terminal amino acids was determinedto be Ala-Pro-Met-Thr-Gln.
Tag/Conjugate
Unconjugated
Alternative Names
IL-3; MCGF; MULTI-CSF
Format
Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration≥100μg/ml.Further dilutions can be made in other aqueou buffers.
Concentration
1 mg/ml (OD280nm, E0.1% =0.84) (prior to lyophilization)
Buffer
Lyophilized fromwater containing 5mg HSA and 4.3mg Sodium chloride
Storage
2-8°C short term, -20°C long term
Introduction
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
Antigen Description
Interleukin-3 (IL-3) is aninterleukin, a type of biological signal (cytokine) that can improve thebody"s natural response to disease as part of the immune system. It acts bybinding to the interleukin-3 receptor. IL-3 stimulates the differentiation ofmultipotent hematopoietic stem cells into myeloid progenitor cells (asopposed to lymphoid progenitor cells where differentiation is stimulated byIL-7) as well as stimulates proliferation of all cells in the myeloid lineage(erythrocytes, megakaryocytes, granulocytes, monocytes, and dendritic cells).It is secreted by basophils and activated T cells to support growth anddifferentiation of T cells from the bone marrow in an immune response.
Keywords
IL3; interleukin 3 (colony-stimulating factor, multiple); interleukin-3; hematopoietic growth factor; IL 3; mast cell growth factor; MCGF; MGC79398; MGC79399; MULTI CSF; multilineage colony stimulating factor; P cell stimulating factor; mast-cell growth f
Citations
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