Human type 1 Creatine Kinase MM Isoenzyme

Name: Human type 1 Creatine Kinase MM Isoenzyme
SKU: DAG281
Rating: 5 (1 reviews)

Human type 1 Creatine Kinase MM Isoenzyme, recombinant protein from P. pastoris

COA

SDS

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Summary

Product Overview

CreatineKinase MM (CK-MM) Type I Isoenzyme. Recombinant full length Creatine KinaseMM isoenzyme without the C-terminal lysine on both subunits. CK-MM is a 47kDa dimeric protein comprised of 2 identical subunits of Type 1 sequence.Purified in the enzymatic

Nature

Recombinant

Tag/Conjugate

Unconjugated

Format

Purified, Liquid

Concentration

Lotspecific. Activity: Lot specific IU/mg total protein. One unit will transferone micromole of phosphate from creatine phosphate to ADP per minute at 37°C.Measured at 340nm as one equimolar amount of NADH produced by coupledreaction.

Buffer

0.01MTris-HCl, 0.075M Sodium chloride, 10mM beta-mercaptoethanol, 50% glycerol, pH7.0 to 7.5

Preservative

0.1% Sodium Azide

Storage

2-8°C short term, -20°C long term

Introduction

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.

Antigen Description

Creatinekinase isoenzymes play a central role in energy transduction in tissues withlarge, fluctuating energy demands, such as skeletal muscle, heart, brain andspermatozoa.

Keywords

Creatine kinase-M; creatine kinase M chain; CKMM; M-CK; CKM; Creatine kinase M-type; creatine kinase, muscle; EC 2.7.3.2

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References

Neutrino mixing in SO(10) GUTs with a non-Abelian flavor symmetry in the hidden sector

PHYSICAL REVIEW D

Authors: Smirnov, Alexei Yu; Xu, Xun-Jie

Abstract

The relation between the mixing matrices of leptons and quarks, U-PMNS approximate to V-CKM(dagger) U-0, where U-0 is a matrix of special forms [e.g., bimaximal (BM) and tribimaximal], can be a clue for understanding the lepton mixing and neutrino masses. It may imply the grand unification and the existence of a hidden sector with certain symmetry that generates U-0 and leads to the smallness of neutrino masses. We apply the residual symmetry approach to obtain U-0. The residual symmetries of both the visible and hidden sectors are Z(2) x Z(2). Their embedding in a unified flavor group is considered. We find that there are only several possible structures of U-0, including the BM mixing and matrices with elements determined by the golden ratio. Realization of the BM scenario based on the SO(10) grand unified theory with the S-4 flavor group is presented. Generic features of this scenario are discussed, in particular, the prediction of CP phase 144 degrees less than or similar to delta(CP) less than or similar to 210 degrees in the minimal version.

MEASUREMENT OF THE CKM ANGLE phi(3) AT BELLE II

ACTA PHYSICA POLONICA B

Authors: Resmi, P. K.

Abstract

The precise measurement of the CKM angle phi(3) is important to further test the Standard Model description of CP violation. The small values of the branching fractions of the decays involved in the measurement limit the precision, hence a larger dataset has to be accumulated to improve the precision. The Belle II experiment at the SuperKEKB asymmetric-energy e(+)e(-) collider aims to collect 50 ab(-1) of data, a factor of 50 more than that of its predecessor Belle. The accelerator has been successfully commissioned in 2016 and the first physics collisions were recorded in April 2018. The best sensitivity to phi(3) can be achieved by harnessing all possible final states of B -> D-(*K-)(()*()) decays. With the full dataset, Belle II is expected to achieve a precision of 1 degrees for the angle phi(3). The expected sensitivities and rediscoveries from 2018 data are presented here.