Recombinant HSV Mosaic Protein (a.a. 140-170, 32-62) [GST]

Product Overview

Recombinant HSV protein fused with a GST tag containing the C-terminal immunodominant regions from ORF65 140-170 a.a. and N-terminal regions from ORF8 32-62 a.a was expressed in E. coli and purified by proprietary chromatographic technique.

Nature

Recombinant

Tag/Conjugate

GST

Buffer

100mM NaCl, 0.1% SDS and 50% glycerol.

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Entry of HSV into the host cell involves interactions of several viral glycoproteins with cell surface receptors. The virus particle is covered by an envelope which, when bound to specific receptors on the cell surface, will fuse with the cell membrane and create an opening, or pore, through which the virus enters the host cell. The sequential stages of HSV entry are analagous to those of other viruses. At first, complementary receptors on the virus and cell surface bring the two membranes into proximity. In an intermediate state, the two membranes begin to merge, forming a hemifusion state. Finally, a stable entry pore is formed through which the viral envelope contents are introduced to the host cell.