HTLV type 1 Glycoprotein 21 (aa 351 - 404) [GST], recombinant protein from E. coli
Recombinant HTLV-I gp21 immunodominant region (a.a. 351-404). Contains a GST fusion partner at the N-terminus, was expressed in E. coli. Reacts with human HTLV-I positive serum.
> 95% pure (SDS-PAGE and HPLC-C4)
60mM Sodium chloride, 50mM Tris-HCl, pH 8.0 containing 0.25% Sarkosil, 10mM glutathione and 50% glycerol
2-8°C short term, -20°C long term
Human T-lymphotropic virus (HTLV) belongs to the family Retroviridae, genus Deltaretrovirus. It is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma in adults and may also be involved in certain demyelinating diseases. Adult T-lymphotropic virus (ATLV) is a strain of this disease that effect primarily adults.
HTLV gp21 (or Transmembrane protein, TM) is a class I integral membrane fusion protein. The fusion activity of Retroviral TMs depends on two membrane-interactive sequences: the N-terminal fusion peptide, which inserts into the target cell membrane, and the C-terminally located transmembrane domain (TMD) that anchors the glycoprotein complex to the viral envelope and infected cell membrane.
HTLV-1; gp21; gp46