HSV type 1 Glycosylated [His] (DAG589)

HSV type 1 Glycosylated (aa 21 - 339) [His], recombinant protein from P. pastoris Datasheet

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Product Overview
Glycosylated recombinant ecto-domain of HSV-1 gD (a.a. 21-339 from KOS strain) representing the external domain of the gD molecule without membrane spanning and cytosolic sequences. It encodes a protein of approximately 30 kDa that contains 3 sites for gl
Nature
Recombinant
Tag/Conjugate
His
Molecular Weight
30 kDa (319aa)
Purity
Purity verified by SDS-PAGE. Purity compares with reference lot.
Format
Purified, Liquid
Concentration
Lot specific (BCA)
Buffer
0.02M Sodium phosphate, 0.00 - 0.1M Sodium chloride, pH 6.7 to 7.7
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as Human herpes virus 1 and 2 (HHV-1 and -2), are two members of the herpes virus family, Herpesviridae, that infect humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus.
Antigen Description
Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell. Glycoprotein D (gD) has been implicated in binding to cellular receptors that facilitate virus penetration into cells. Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) is an essential component of the entry apparatus that is responsible for viral penetration and subsequent cell-cell spread.
Keywords
Herpesviridae; Alphaherpesvirinae; Simplexvirus; Herpes simplex virus 1; HSV-1; Herpes simplex virus 2; HSV-2; Herpes simplex virus; HSV 1&2; Herpes Simplex Virus Type 1 & 2; HSV1 + HSV2 gD; Envelope glycoprotein D; GD; Glycoprotein D; US6

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HSV type 1 (DAG181)

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