HIV Glycoprotein 41 (subtype O ) [MBP] (DAG1555)

HIV Glycoprotein 41 (subtype O ) [MBP], recombinant protein from E. coli Datasheet

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Product Overview
HIV Type-O gp41 MBP tag Recombinant- is a non-glycosylated 60 kDa polypeptide chain, containing the envelope glycoprotein 41 (subtype-B) gene of the HIV having maltose binding protein tag on the N-terminus.
Nature
Recombinant
Tag/Conjugate
MBP
Purity
Greater than 95.0% as determined by HPLC analysis and SDS-PAGE.
Format
Sterile filtered colorless clear solution.
Buffer
20mM sodium carbonate, pH-9.6, 0.02 % sodium azide.
Storage
2-8°C short term, -20°C long term
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
Antigen Description
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes
Keywords
env; Glycoprotein 41; gp41; TM; Transmembrane protein; HIV gp41 L

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