HIV type 1 P31 Integrase protein [GST] (DAG1544)

HIV type 1 P31 Integrase protein [GST], recombinant protein from E. coli Datasheet

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Product Overview
The E.coli derived recombinant protein is a non-glycosylated polypeptide chain, containing the HIV-1 immunodominant regions from the p31 protein (integrase) 9-289 amino acids, fused with a GST tag at N-terminus.
Nature
Recombinant
Tag/Conjugate
GST
Purity
Greater than 95.0% as determined by HPLC analysis and SDS-PAGE.
Format
Sterile filtered colorless clear solution.
Buffer
1.5M urea, 25mM Tris-HCl pH 8.0, 0.2% Triton-X, 50% Glycerol.
Storage
2-8°C short term, -20°C long term
Introduction
Integrase is an enzyme produced by the HIV which enables its genetic material to be integrated into the DNA of the infected cell and is a key component in the pre-integration complex. HIV integrase contains 3 domains, an N-terminal HH-CC zinc fingerdomainwhich is partially responsible for multimerization, a central catalytic domain and a C-terminal domain. Both Central catalytic domain and C-terminal domains have been shown to bind both viral and cellular DNA. No crystal structure data exists with Integrase bound to its DNA substrates. HIV-1 integrase functions as a dimeror a tetramer. Additionally, several host cellular proteins interact with integrase and may facilitate the integration process.
Antigen Description
Integrase is an enzyme produced by the HIV which enables its genetic material to be integrated into the DNA of the infected cell and is a key component in the pre-integration complex. HIV integrase contains 3 domains, an N-terminal HH-CC zinc fingerdomainwhich is partially responsible for multimerization, a central catalytic domain and a C-terminal domain. Both Central catalytic domain and C-terminal domains have been shown to bind both viral and cellular DNA. No crystal structure data exists with Integrase bound to its DNA substrates. HIV-1 integrase functions as a dimeror a tetramer. Additionally, several host cellular proteins interact with integrase and may facilitate the integration process

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