HIV type 1 Glycoprotein 41 [Biotin] (DAG1526)
HIV type 1 Glycoprotein 41 (aa 466 - 753) [Biotin], recombinant protein from E. coli
Datasheet
Product Overview
HIV-1 gp41 Biotin labeled is a non-glycosylated polypeptide chain, containing 288 amino acids (466-753 a.a.) and having a Mw of 32kDa. HIV1 gp41 biotin labeled is fused to a 114kDa beta-galactosidase tag at N-terminus having a total Mw of 146kDa.
Nature
Recombinant
Tag/Conjugate
Biotin
Purity
Greater than 95.0% as determined by SDS-PAGE.
Format
Sterile filtered colorless clear solution.
Concentration
1 mg/ml
Buffer
1 mg/ml in 20mM Tris-HCl pH-8, 20mM B-ME and 8M urea.
Storage
2-8°C short term, -20°C long term
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
Antigen Description
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes
Keywords
env; Glycoprotein 41; gp41; TM; Transmembrane protein; HIV gp41 L
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