HIV type 1 Nef [His], recombinant protein from E. coli
C-terminal 6xHis tagged HIV-1 Nef (Clade C) protein
Each vial contains 100 μg of lyophilized protein in 500mM NaCl, 50mM Phosphat buffer (pH 7.4), 200mM Imidazole, 8M urea.
2-8°C short term, -20°C long term
HIV-1 is the most common and pathogenic strain of the virus. Scientists divide HIV-1 into a major group (Group M) and two or more minor groups. Each group is believed to represent an independent transmission of SIV into humans (but subtypes within a group are not). A total of 39 ORFs are found in all six possible reading frames (RFs) of HIV-1 complete genome sequence, but only few of them are functional.
Nef (Negative Regulatory Factor) is a protein expressed by primate lentiviruses. These include human immunodeficiency viruses (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV). Nef is one of many pathogen-expressed proteins, known as virulence factors, which function to manipulate the host's cellular machinery and thus allow infection, survival or replication of the pathogen. Nef stands for "Negative Factor".
HIV-1 Nef; Human immunodeficiency virus type 1 Nef