HIV Glycoprotein 41 (aa 541 - 682) [His], recombinant protein from P. pastoris
Recombinant ecto-domain of HIV-1 gp41 (amino acids 541-682 from strain HxB2), Contains a 6 histidine fusion partner, was expressed in Pichia pastoris, reacts with HIV-1 positive human sera and monoclonal antibodies specific for conformational and linear e
Purity verified by SDS-PAGE. Purity compares with reference lot.
1M Urea, 0.02M Sodium phosphate, 0.5M Sodium chloride, pH 7.0 to 8.0
2-8°C short term, -20°C long term
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
env; Glycoprotein 41; gp41; TM; Transmembrane protein; HIV gp41 L