HIV type 1 Envelope Antigen Gp41 (Envelope Antigen a.a. 466-753) (DAG569)

HIV type 1 Envelope Antigen Gp41 (aa 466 - 753) (Envelope Antigen a.a. 466-753), recombinant protein from E. coli Datasheet

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Product Overview
Recombinant Human Immunodeficiency Virus Type 1 Envelope Antigen, Gp41 (a.a. 466-753). a.a 466 to a.a 753 of the HIV-1 env region (Strain IIIB). 32kDa with Beta-galactosidase (114kDa) fused at the N-terminus. Reacts strongly with human HIV positive serum.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Purity
> 95% pure (SDS-PAGE)
Format
Purified, Liquid
Concentration
1 mg/ml (OD280nm)
Buffer
8M Urea, 20mM Tris-HCl, pH 8.0; 10mM Beta-mercaptoethanol
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.
Antigen Description
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
Keywords
env; Glycoprotein 41; gp41; TM; Transmembrane protein; HIV gp41 L

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