HIV Glycoprotein 120, recombinant protein from E. coli
Human Immunodeficiency Virus Type 1 (HIV-1), Recombinant The recombinant protein contains the C-terminus of gp120 and most of gp41. Does not contain a fusion partner. Molecular weight is 27. 3 kDa.
> 95% pure (10% PAGE, coomassie staining). S-Sepharose> Ceramic Hydroxyapatite> S-300
50 mM Tris, pH 8. 0, containing 0. 1% SDS, 5 mM DTT, 2. 5 mM EDTA
2-8°C short term, -20°C long term
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
Glycoprotein 120; Glycoprotein 41; HIV1 gp120; HIV1 gp41; SUvTM; HIV1 gp120/gp41; Human Immunodeficiency Virus Type 1 gp120; Human Immunodeficiency Virus Type 1 gp41