Product Overview
Recombinant Hepatitis C Virus antigen (66 kDa), contains an artificial mosaic polypeptide composite constructed from fragments of the NS-4 immunodominant region of 11 different HCV genotypes and a GST fusion partner, was expressed in E. coli, and puried i
Purity
> 95% pure (10% PAGE coomassie staining). S-Sepharose and Ceramic Hydroxyapatite and Affinity purification
Buffer
8M urea, 20mM TRIS, pH 9.0 containing 10mM DTT, 1mM EDTA and 0.5% Tween-20
Storage
2-8°C short term, -20°C long term
Introduction
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Keywords
HCV; HCV NS4; Hepatitis C Virus nonstructural antigen 4; Non structural protein 4A; Non structural protein 4B; NS4A; NS4B; Flaviviridae; Hepacivirus; Hepatitis C virus; p27; p8; Hepatitis C Virus NS4
Citations
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