HCV Core Antigen (DAG571)

HCV Core Antigen (aa 2 - 192), recombinant protein from E. coli Datasheet

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Product Overview
Recombinant Hepatitis C Virus (HCV) Core Antigen (amino acids 2-192) reactive with human HCV positive serum. It is 22kDa, with a Beta-galactosidase (114kDa) fused at the N-terminus, was expressed in E. coli.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Molecular Weight
22kDa
Purity
> 95% pure (SDS-PAGE)
Format
Purified, Liquid
Concentration
1 mg/ml (OD280nm)
Buffer
8M urea, 20mM Tris-HCl, pH 8.0, 10mM beta-mercaptoethanol
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Antigen Description
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Keywords
Core protein p19; HCcAg; HCV core antigen; HCV core protein; Hepatitis C Virus core protein;

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