HCV Core, Nonstructural Protein 3, Nonstructural Protein 4, Nonstructural Protein 5 [His] (DAG468)

HCV Core, Nonstructural Protein 3, Nonstructural Protein 4, Nonstructural Protein 5 [His], recombinant protein from E. coli

Product Overview
Recombinant Hepatitis C virus Core antigen, contains the HCV core, NS3, NS4 and NS5 immunodominant regions and a 6-His fusion partner, was expressed in E. coli, and puried in vitro using proprietary chromatographic technique.
Nature
Recombinant
Tag/Conjugate
His
Procedure
0.5mM EDTA
Purity
> 95% pure (10% PAGE (Coomassie)). Proprietary chromatographic technique
Format
Purified, Liquid
Concentration
3 mg/ml
Buffer
50mM Tris-HCl, pH 8.0 containing 8M Urea, 0.5mM EDTA and 0.15mM DTT
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Keywords
Core protein p19; HCcAg; HCV core antigen; HCV core protein; Hepatitis C Virus core protein;

Citations


Have you cited DAG468 in a publication? Let us know and earn a reward for your research.

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket