HCV Core Antigen [His] (DAG594)

HCV Core Antigen [His], recombinant protein from P. pastoris Datasheet

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Product Overview
Recombinant Hepatitis C Virus (HCV) Nucleocapsid protein (p22). Amino acids 1-120 encodes a 16 kDa protein. Contains a 6 histidine fusion partner. Appears as a monomer at ~19kDa on Western blots (also as a dimer at ~34 kDa at higher loads). It was express
Nature
Recombinant
Tag/Conjugate
His
Molecular Weight
16 kDa (120aa)
Purity
Purity verified by SDS PAGE. Purity compares with reference lot.
Format
Purified, Liquid
Concentration
Lot specific
Buffer
0.05M Sodium phosphate, 0.15M Sodium chloride, pH 6.5 to 8.5
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Antigen Description
Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection.
Keywords
Core protein p19; HCcAg; HCV core antigen; HCV core protein; Hepatitis C Virus core protein;

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