EBV NA1 [GST] (DAG2362)

EBV NA1 (aa 1 - 90, 408 - 498) [GST], recombinant protein from E. coli

Product Overview
The E.Coli derived recombinant mosaic protein contains the HHV-4 EBNA regions, 1-90, 408-498 amino acids, the Mw is 46kDa (including 26kDa GST tag).
> 95%, based on SDS PAGE
Each vial contains 100 μg of lyophilized protein in 50mM Tris-HCl pH 8, 10mM glutation, 60mM NaCl and 0.5% sarcosyl.
2-8°C short term, -20°C long term
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10, 000 nucleotides and encodes a single polyprotein of about 3, 000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Several different genotypes of HCV with slightly different genomic sequences have since been identified that correlate with differences in response to treatment with interferon alpha.
Antigen Description
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
HCV NS5; Hepatitis virus NS5A; Non structural protein 5A; NS5A; p56; NS5B; HCV-2 NS5; Hepatitis C Virus NS5, genotype 6a; Flaviviridae; Hepacivirus


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EBV-Positive Primary Large B-Cell Lymphoma: The Role of Immunohistochemistry and XPO1 in the Diagnosis of Mediastinal Lymphomas


Authors: Maracaja, Danielle L. V.; Puthenpura, Vidya; Pels, Salley G.; O'Malley, Dennis P.; Sklar, Jeffrey L.; Finberg, Karin E.; Xu, Mina L.

Primary mediastinal (thymic) large B-cell lymphoma (PMBL) is described as almost always negative for Epstein-Barr virus (EBV). In the context of a mediastinal lymphoma, the distinction between PMBL, classical Hodgkin lymphoma, diffuse large B-cell lymphoma, and mediastinal gray-zone lymphoma can be very difficult; hence, EBV positivity often argues against PMBL. We present a 19-year-old man with mediastinal mass morphologically consistent with PMBL. The tumor expressed classic immunophenotype, including positivity for CD20, CD19, MAL, OCT2, BOB1, BCL6, CD79a, and subset positivity for CD30. However, the tumor was EBV-positive by in situ hybridization. Next-generation sequencing detected somatic mutations in XPO1 (E571K), SMARCB1 (L356fs), and MYCC (T73A). Although the immunophenotype and XPO1 mutation are characteristic of PMBL, EBV expression is uncommon. Since EBV positivity can occur in rare PMBLs, it should not be the deciding factor in the diagnosis. This is the first EBV-positive PMBL in which mutational profiling has been reported. Aside from providing diagnostic support, the finding of the XPO1 E571K mutation may suggest a targeted therapeutic option.

Fibrin-associated diffuse large B-cell lymphoma with plasmacytic differentiation: case report and literature review


Authors: Moreno Moreno, Esther; Ferrer-Gomez, Ana; Pian Arias, Hector; Garcia Garcia, Irene; Garcia-Cosio, Monica

BackgroundPrimary cardiac lymphomas are extremely rare entities (<2% of cardiac tumours) and the most frequent histologic type is diffuse large B-cell lymphoma (DLBCL). Fibrin-associated DLBCL (FA-DLBCL) is a very unusual form of DLBCL associated with chronic inflammation, and only case reports and small series have been described. In the heart, it usually occurs in the context of a cardiac myxoma or cardiac prostheses and it is not bulk forming. These lymphomas frequently present with non-germinal center phenotype and are associated with Epstein-Barr virus (EBV) type III latency.Case presentationWe describe a case of FA-DLBCL arising in a cardiac myxoma, with plasmacytic differentiation and type I EBV latency.ConclusionsAlthough they are very rare, FA-DLBCLs should be known for their diagnostic difficulty, due to its unspecified clinical manifestations, and for their more favourable prognosis, sometimes even without additional treatment after surgical resection.

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