Recombinant Epstein Barr Virus Nuclear Antigen Type 1, was expressed in Sf-9/Baculovirus, and puried in vitro using conventional chromatography techniques.
Ion exchange chromatography
0.4 mg/ml (BCA)
20mM Tris, 6M Urea, pH 8.0
2-8°C short term, -20°C long term
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of the herpes family, and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis (glandular fever). It is also associated with particular forms of cancer, such as Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and conditions associated with human immunodeficiency virus (HIV) such as hairy leukoplakia and central nervous system lymphomas.
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1; Epstein Barr virus; HHV4; Human Herpesvirus 4; EBV Nuclear Antigen