EBV type 1 Nuclear Antigen (DAG551)

EBV type 1 Nuclear Antigen, recombinant protein from Baculovirus

Product Overview
Recombinant Epstein Barr Virus Nuclear Antigen Type 1, was expressed in Sf-9/Baculovirus, and puried in vitro using conventional chromatography techniques.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Molecular Weight
~88kDa
Procedure
None
Purity
Ion exchange chromatography
Format
Purified, Liquid
Concentration
0.4 mg/ml (BCA)
Buffer
20mM Tris, 6M Urea, pH 8.0
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of the herpes family, and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis (glandular fever). It is also associated with particular forms of cancer, such as Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and conditions associated with human immunodeficiency virus (HIV) such as hairy leukoplakia and central nervous system lymphomas.
Antigen Description
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
Keywords
EBNA1; EBV nuclear antigen 1; Epstein Barr nuclear antigen 1; Epstein Barr virus; HHV4; Human Herpesvirus 4; EBV Nuclear Antigen

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References


XIE, KW; SNYDER, M; et al. 2 SHORT AUTOEPITOPES ON THE NUCLEAR DOT ANTIGEN ARE SIMILAR TO EPITOPES ENCODED BY THE EPSTEIN-BARR-VIRUS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92:1639-1643(1995).
Cook, AD; Davies, JM; et al. Mimotopes identified by phage display for the monoclonal antibody CII-C1 to type II collagen. JOURNAL OF AUTOIMMUNITY 11:205-211(1998).

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