Recombinant Epstein Barr Virus antigen, contains the the EBV (HHV-4) Early Antigen D immunodominant region and a GST fusion partner, has the molecular weight of 34kDa, was expressed in E. coli, and puried in vitro using conventional chromatography techniq
> 95% pure (10% PAGE, coomassie staining). GS-4B Sepharose Affinity Purification
50mM Tris-HCl, pH 8, 10mM Glutathione, 60mM Sodium chloride, 0.5% sarcosyl, 50% glycerol
2-8°C short term, -20°C long term
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of the herpes family, which includes herpes simplex virus 1 and 2, and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis. It is also associated with particular forms of cancer, particularly Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas associated with HIV. Finally, there is evidence that infection with the virus is associated with a higher risk of certain autoimmune diseases, especially dermatomyositis, systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis.
The EBV Early Diffuse Antigen Diffuse EA-D or EBV DNA polymerase accessory protein, is an essential component of the viral DNA polymerase and is required for lytic EBV replication. In addition to its polymerase accessory protein function, it has recently been reported that Ea-D is a transcriptional activator, inducing expression of the essential oriLyt promoter, BHLF1.
EBV Early Antigen-R Homologue Bcl-2; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus; Human herpesvirus 4 (HHV-4); EA-R