EBV Early Antigen D [GST] (DAG543)

EBV Early Antigen D [GST], recombinant protein from E. coli

Product Overview
Recombinant Epstein Barr Virus antigen, contains the the EBV (HHV-4) Early Antigen D immunodominant region and a GST fusion partner, has the molecular weight of 34kDa, was expressed in E. coli, and puried in vitro using conventional chromatography techniq
Nature
Recombinant
Tag/Conjugate
GST
Molecular Weight
34 kDa
Procedure
None
Purity
> 95% pure (10% PAGE, coomassie staining). GS-4B Sepharose Affinity Purification
Format
Purified, Liquid
Concentration
1 mg/ml
Buffer
50mM Tris-HCl, pH 8, 10mM Glutathione, 60mM Sodium chloride, 0.5% sarcosyl, 50% glycerol
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
The Epstein–Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of the herpes family, which includes herpes simplex virus 1 and 2, and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis. It is also associated with particular forms of cancer, particularly Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas associated with HIV. Finally, there is evidence that infection with the virus is associated with a higher risk of certain autoimmune diseases, especially dermatomyositis, systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis.
Antigen Description
The EBV Early Diffuse Antigen Diffuse EA-D or EBV DNA polymerase accessory protein, is an essential component of the viral DNA polymerase and is required for lytic EBV replication. In addition to its polymerase accessory protein function, it has recently been reported that Ea-D is a transcriptional activator, inducing expression of the essential oriLyt promoter, BHLF1.
Keywords
EBV Early Antigen-R Homologue Bcl-2; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus; Human herpesvirus 4 (HHV-4); EA-R

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References


Dohno, S; Maeda, A; et al. Diagnosis of infectious mononucleosis caused by Epstein-Barr virus in infants. PEDIATRICS INTERNATIONAL 52:536-540(2010).
Waubant, E; Mowry, EM; et al. Common viruses associated with lower pediatric multiple sclerosis risk. NEUROLOGY 76:1989-1995(2011).

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