EBV EBNA1 [GST] (DAG1850)

EBV EBNA1 [GST], recombinant protein from E. coli

Product Overview
EBNA1 (EBV) (P03211) partial recombinant protein with GST tag expressed inEscherichia coli .
Nature
Recombinant
Tag/Conjugate
GST
Procedure
None
Purity
Ion exchange column and HPLC reverse phase column
Format
Lyophilized
Buffer
Lyophilized from 50 mM Tris-HCl, 60mM NaCl, pH 8 (10 mM glutation, 0.5% sarcosyl)
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
Epstein Barr virus (EBV) is a member of the herpes virus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt"s lymphoma, nasopharyngeal carcinoma and Hodgkin"s disease.
Antigen Description
Epstein-Barr Virus (EBV) is a member of the herpesvirus family (Gamma subgroup, DNA virus of 120-200 nm) and one of the most common Human viruses. The virus occurs worldwide, and most people become infected with EBV sometime during their lives. Transmission of the virus is almost impossible to prevent since many healthy people can carry and spread the virus intermittently for life. Infants become susceptible to EBV as soon as maternal antibody protection disappears. Infection of children usually causes no symptoms. Infection during adolescence or young adulthood causes infectious mononucleosis 35 % to 50 % of the time. Infectious mononucleosis is almost never fatal. There are no known associations between active EBV infection and problems during pregnancy, such as miscarriages or birth defects. Although the symptoms of infectious mononucleosis usually resolve in 1 or 2 months, EBV remains dormant or latent in a few cells in the throat and blood for the rest of the person's life. Periodically, the virus can reactivate and is commonly found in the saliva of infected persons. This reactivation usually occurs without symptoms of illness. EBV also establishes a lifelong dormant infection in some cells of the body's immune system. A late event in a very few carriers of this virus is the emergence of Burkitt′s lymphoma and nasopharyngeal carcinoma, but EBV is probably not the sole cause of these malignancies.
Keywords
Epstain-Barr Virus EBNA1; EBV EBNA1; Epstain-Barr Virus; EBV; EBV EBNA1; Epstein-Barr Virus EBNA1

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References


Kitagawa, N; Goto, M; et al. Epstein-Barr virus-encoded poly(A)- RNA supports Burkitt's lymphoma growth through interleukin-10 induction. EMBO JOURNAL 19:6742-6750(2000).
Imadome, KI; Yajima, M; et al. Novel Mouse Xenograft Models Reveal a Critical Role of CD4(+) T Cells in the Proliferation of EBV-Infected T and NK Cells. PLOS PATHOGENS 7:-(2011).

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