E. coli NfnB Protein [His] (DAG2433)

E. coli NfnB Protein (aa 1 - 217) [His], recombinant protein from E. coli Datasheet

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Product Overview
This is a nfnB Protein (a.a.1-217). E.coli recombinant protein expressed in E. coli. His tag increases overall size to a.a. 237
Nature
Recombinant
Tag/Conjugate
His
Purity
Protein
Concentration
1 mg/ml
Buffer
In 20 mM Tris-HCl buffer (pH8.0) containing 50mM Nacl, 1mM DTT, 10% glycerol
Storage
2-8°C short term, -20°C long term
Introduction
Nitroreductase shows the ability to reduce quinines. It is an enzyme for activating prodrugs in antibody directed enzyme prodrug therapy. It is also capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
Antigen Description
NFNB, also known as NFSB, shows the ability to reduce quinines. This protein is an enzyme for activating prodrugs in antibody directed enzyme prodrug therapy. It also capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
Keywords
Dihydropteridine reductase; dprA; FMN dependent nitroreductase; nfnB; nfsI; ntr; Oxygen insensitive NAD(P)H nitroreductase; Escherichia coli Nitroreductase; E. coli Nitroreductase; Enterobacteriaceae; Escherichia; E. coli

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