E. coli AmpC (aa 20 - 377) [His], recombinant protein from E. coli
Escherichia coli ampC (NP_418574, 20 a.a. - 377 a.a.) partial recombinant protein with His tag expressed inEscherichia coli .
In 20 mM Tris-HCl, pH 8.0 (10% glycerol)
2-8°C short term, -20°C long term
False positive lipoprotein prediction. The ampC -lactamase gene encodes a serine cephalosporinase .
The beta lactam antibiotics (penicillins and cephalosporins) are the most frequently used antimicrobial agents. All of the beta lactams are structurally related through the presence of a core beta lactam ring. Bacterial resistance to beta lactams continues to increase, primarily due to the production of beta lactamases. Beta lactamases catalyze the hydrolysis of the beta lactam bond, which destroys antibacterial activity. Bacteria that produce TEM type or SHV type beta lactamases have point mutations in structural genes that have extended the substrate specificity of these beta lactamases. As a result, many of the beta lactamase producing Gram negative pathogens have become multidrug resistant.