E. coli Glucose 6 Phosphate Dehydrogenase Protein (DAG2420)

E. coli Glucose 6 Phosphate Dehydrogenase Protein (aa 1 - 491), recombinant protein from E. coli Datasheet

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Product Overview
Escherichia coli zwf (NP_416366, a.a. 1-491) full-length recombinant protein expressed in Escherichia coli.
Nature
Recombinant
Tag/Conjugate
Unconjugated
Purity
Protein
Concentration
Please see the vial label for concentration
Buffer
In 50 mM MES, pH 6.0 (0.1 mM PMSF, 2 mM EDTA, 0.5 mM DTT, 10% glycerol)
Preservative
No Preservative
Storage
2-8°C short term, -20°C long term
Introduction
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Antigen Description
Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway, a metabolic pathway that supplies reducing energy to cells by maintaining the level of NADPH. G6PD converts glucose-6-phosphate into 6-phosphoglucono-delta-lactone and simultaneously produce NADPH. The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage. G6PD deficiency cause acute hemolytic anemia.
Keywords
G6PD; glucose-6-phosphate dehydrogenase; G6PD1; glucose-6-phosphate 1-dehydrogenase; E.coli G6PD; Escherichia coli G6PD; Enterobacteriaceae; Escherichia; E. coli

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