DENV type 2 [GST] (DAG1661)

DENV type 2 [GST], recombinant protein from E. coli

Product Overview
Recombinant DENV NS1 protein fused to a GST tag was expressed in E. coli and purified by proprietary chromatographic technique.
Nature
Recombinant
Tag/Conjugate
GST
Procedure
None
Purity
> 95% pure as determined by 10% PAGE (coomassie staining).
Buffer
50mM Tris-Hcl pH 8.0, 60mM NaCl, 10mM glutathione and 50% glycerol.
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown. Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever.
Antigen Description
NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown. Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever.
Keywords
Dengue NS1; Dengue Virus non-structural protein 1; Dengue Virus NS1 glycoprotein; DENV NS1

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