Recombinant Dengue Type-3 NS1 immunodominant regions. Contains a 6-His fusion partner, was expressed in E. coli.
> 95% pure (12% SDS-PAGE (Coomassie)). Proprietary chromatographic technique
2-8°C short term, -20°C long term
Caused by one of four closely related virusserotypesof the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and mice Morpholinoantisense oligos have shown specific activity against Dengue virus.
Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shocksyndromeprotein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.
Dengue NS1; Dengue Virus non-structural protein 1; DENE; DENE NS1; DEN-2