Recombinant Dengue Virus NS1 protein, full length Type 2 immunodominant regions. Contains a 6-His tag.
> 90% pure (10% SDS-PAGE, Coomassie staining) Purified by proprietary chromatographic technique
100mM Tris HCl, pH 8.0 containing 8M Urea and 200mM Sodium chloride
2-8°C short term, -20°C long term
Dengue virus (DENV) in one of four serotypes is the cause of dengue fever. It is a mosquito-borne single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. All four serotypes can cause the full spectrum of disease. Its genome is about 11000 bases that codes for three structural proteins, capsid protein C, membrane protein M, envelope protein E; seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5 and 3 ends. Further classification of each serotype into genotypes often relates to the region where particular strains are commonly found or were first found.
NS1 is essential for viral viability but its precise biological function is unknown. Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever.
Dengue Virus 1+2+3+4; Dengue Virus Type 1, 2, 3, 4; Group IV; Flaviviridae; Flavivirus; Dengue virus; Dengue Virus; DENV