Recombinant Dengue Type-1 Envelope Domain III (amino acids 300-400) immunodominant regions. This region contains neutralizing epitopes, and receptor binding domain. Reacts with Dengue Type 1 IgG. Contains a 6-His fusion partner. It was expressed in E. col
12 kDa (300-400aa)
> 95% pure (10% PAGE (Coomassie)). Proprietary chromatographic technique.
2-8°C short term, -20°C long term
Dengue virus (DENV) in one of four serotypes is the cause of dengue fever. It is a mosquito-borne single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. All four serotypes can cause the full spectrum of disease. Its genome is about 11000 bases that codes for three structural proteins, capsid protein C, membrane protein M, envelope protein E; seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5' and 3' ends. Further classification of each serotype into genotypes often relates to the region where particular strains are commonly found or were first found.
The DENV E (envelope) protein, found on the viral surface, is important in the initial attachment of the viral particle to the host cell. Several molecules which interact with the viral E protein (ICAM3-grabbing non-integrin. CD209, Rab 5, GRP 78 and The Mannose Receptor) have been shown to be important factors mediating attachment and viral entry.
DENV; Dengue Virus Envelope Protein; DENV Envelope Protein; Dengue virus