DENV type 1 Envelope protein [His] (DAG450)

DENV type 1 Envelope protein (aa 300 - 400) [His], recombinant protein from E. coli

Product Overview
Recombinant Dengue Type-1 Envelope Domain III (amino acids 300-400) immunodominant regions. This region contains neutralizing epitopes, and receptor binding domain. Reacts with Dengue Type 1 IgG. Contains a 6-His fusion partner. It was expressed in E. col
Nature
Recombinant
Tag/Conjugate
His
Molecular Weight
12 kDa (300-400aa)
Procedure
None
Purity
> 95% pure (10% PAGE (Coomassie)). Proprietary chromatographic technique.
Format
Purified, Liquid
Concentration
4.14 mg/ml
Buffer
PBS, pH 7.4
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
Dengue virus (DENV) in one of four serotypes is the cause of dengue fever. It is a mosquito-borne single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. All four serotypes can cause the full spectrum of disease. Its genome is about 11000 bases that codes for three structural proteins, capsid protein C, membrane protein M, envelope protein E; seven nonstructural proteins, NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5' and 3' ends. Further classification of each serotype into genotypes often relates to the region where particular strains are commonly found or were first found.
Antigen Description
The DENV E (envelope) protein, found on the viral surface, is important in the initial attachment of the viral particle to the host cell. Several molecules which interact with the viral E protein (ICAM3-grabbing non-integrin. CD209, Rab 5, GRP 78 and The Mannose Receptor) have been shown to be important factors mediating attachment and viral entry.
Keywords
DENV; Dengue Virus Envelope Protein; DENV Envelope Protein; Dengue virus

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