DENV type 1 Nonstructural Protein 1 (DAG3062)

DENV type 1 Nonstructural Protein 1 (aa 777 - 1131), recombinant protein from Baculovirus

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Summary
Documentation

Product Overview

Recombinant Dengue Virus Type 1 NS1 Protein

Nature

Recombinant

Tag/Conjugate

Unconjugated

Procedure

5 mM EDTA

Purity

≥ 95% on 12.5% SDS-PAGE

Concentration

≥ 1 mg/ml by Bradford dye assay

Buffer

1X PBS, pH7.4

Preservative

0.1% Thimerosal

Storage

2-8°C short term, -20°C long term

Introduction

NS1 is one of 7 Dengue Virus non-structural proteins which are thought to be involved in viral replication. NS1 exists as a monomer in its immature form but is rapidly processed in the endoplasmic reticulum to form a stable dimer. A small amount of NS1 remains associated with intracellular organelles where it is thought to be involved in viral replication. The rest of NS1 is found either associated with the plasma membrane or secreted as a soluble hexadimer. NS1 is essential for viral viability but its precise biological function is unknown. Antibodies raised in response to NS1 in viral infection can cross react with cell surface antigens on epithelial cells and platelets and this has been implicated in the development of Dengue Hemorrhagic fever.

Antigen Description

Keywords

Dengue NS1; Dengue Virus non-structural protein 1; Dengue Virus NS1 glycoprotein; DENV NS1