Recombinant Chikungunya E1 Antigen (DAGA-161)

Chikungunya E1 Antigen, Recombinant protein from E. coli

Alternative Names
CHIKV; Chikungunya Virus; Chikungunya E1; Chikungunya E2; CHIKV E1; CHIKV E2
Batch dependent - please inquire should you have specific requirements.
1mg, 10mg
Antigen Description
Chikungunya is an infection caused by the chikungunya virus. The disease features the sudden onset of fever two to four days after exposure. The fever usually lasts two to seven days, while accompanying joint pains typically last weeks or months but sometimes years. The mortality rate is a little less than 1 in 1,000; the elderly or those with underlying chronic medical problems are most likely to have severe complications.
CHIKV;Chikungunya Virus;Chikungunya E1;Chikungunya E2;CHIKV E1;CHIKV E2


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Pathogenic Th1 responses in CHIKV-induced inflammation and their modulation upon Plasmodium parasites co-infection


Authors: Torres-Ruesta, Anthony; Teo, Teck-Hui; Chan, Yi-Hao; Renia, Laurent; Ng, Lisa F. P.

The induction of polyarthritis and polyarthralgia is a hallmark of arthritogenic alphavirus infections, with an exceptionally higher morbidity observed with chikungunya virus (CHIKV). While the mechanisms underlying these incapacitating acute symptoms remain partially understood, the progression to chronic conditions in some cases remains unanswered. The highly pro-inflammatory nature of alphavirus disease has suggested the involvement of virus-specific, joint-infiltrating Th1 cells as one of the main pathogenic mediators of CHIKV-induced joint pathologies. This review summarizes the role of cell-mediated immune responses in CHIKV pathogenesis, with a specific focus on pro-inflammatory Th1 responses in the development of CHIKV joint inflammation. Furthermore, due to the explosive nature of arthritogenic alphavirus outbreaks and their recent expansion across the world, co-infections with other highly prevalent pathogens such as malaria are likely to occur but the pathological outcomes of such interactions in humans are unknown. This review will also discuss the potential impact of malaria co-infections on CHIKV pathogenesis and their relevance in alphavirus control programs in endemic areas.



Authors: Solomon, Lydia; Kumar, Nitin; Singh, Navjot

BACKGROUND Chikungunya Fever, though known to be a self-limiting disease, causes severe disabling joint involvement, which in turn lays a significant burden on the health care system. Although mortality related to this illness is low, there is significant interference with the ability of a patient to perform routine daily activities due to polyarthritis. The objective of our study is thus to analyse the clinical profile of patients with Chikungunya fever. METHODS OPD and IPD patients with symptoms of fever and joint pains who presented to a tertiary care center in Ludhiana, Punjab were included in the study. They were tested for Chikungunya (CHIKV IgM antibody) and those who were positive (confirmed cases) were in turn recruited to the study. Their clinical profiles, laboratory features, complications and outcomes were studied. RESULTS A total of 88 patients formed our study group, all of whom tested positive for CHIKV IgM antibody. Male: Female ratio was 1:1.3, with the mean age of patients enrolled being 43 +/- 18.4 years. A majority, 18 (20.5%) of them were in the 31-40-year age group. Most of the patients i.e. 72 (81.8%) presented within the first 7 days of illness. The main symptom was fever, seen in 67 (76.3%) patients. The knee joint was seen to be involved in a majority of patients 60(68.2%), followed by the elbow joint in 40 (45.5%) of them. Diabetes mellitus was the most commonly observed co-morbidity, seen in 15 (17%) patients. Co-infection with Dengue was seen in 8 (9.1%) patients, 1 of whom died. 8 (9.1%) patients demonstrated leucopenia, while 52 (59.1%) had transaminitis. While 67 (76%) patients required treatment on IPD basis. The mean duration of hospital stay was 4 +/- 3.96 days. 29 (33%) patients required the administration of steroids in addition in NSAIDs. Also, 37 (42%) had arthritis on follow up. Overall, 86 (97.7 %) patients were discharged while 2 (2.3%) expired. Both of these patients had documented multisystemic involvement. CONCLUSIONS Chikungunya fever, though a self-limiting disease can be very debilitating, and in its severe form, can cause multiorgan involvement and mortality.

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