Recombinant Borrelia spielmanii OspC antigen. Expressed in E. coli bacterial cells. Full-length cDNA coding for Borrelia spielmanii OspC fused to a hexahistidine purification tag.

Recombinant

His

neutral to slightly alkaline pH and 20 % glycerol as cryoprotective agent.

2-8°C short term, -20°C long term

Lyme disease is a multisystemic infectious disease caused by Borrelia species. In the United States Borrelia burgdorferi is the main cause of Lyme disease,in Europe the most dominant species are Borrelia afzelii and Borrelia garinii. Another, even though relatively rare species is Borrelia spielmanii. Lyme disease is the most common tick-borne disease in the Northern Hemisphere. Borrelia is transmitted by the bite of infected ticks from the genus Ixodes. The various clinical manifestations in early disease stage include flu-like symptoms and a characteristic circular skin rash called erythema migrans. Left untreated, the disease is characterized by chronic infection of the joints, heart,and central nervous system. Delayed or inadequate treatment can lead to the serious late manifestations, which can be disabling and difficult to treat.

Outer Surface Protein C, or ospC, is a 20.7 kDa immunogenic protein on the outer surface of the spirochete Borrelia burgdorferi. Its function is not known, but it is located with lipid-anchoring sites on the outer cell membrane.

Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia; Borrelia garinii; Borrelia burgdorferi (Lyme); Borrelia burgdorferi; Lyme; Borrelia burgdorferi garini; B. spielmanii OspC protein; Borrelia spielmanii outer surface protein C; OspC; outer