B. spielmanii OspC [His] (DAG2666)

Recombinant B. spielmanii OspC from E. coli [His]

Product Overview
Recombinant Borrelia spielmanii OspC antigen. Expressed in E. coli bacterial cells. Full-length cDNA coding for Borrelia spielmanii OspC fused to a hexahistidine purification tag.
Alternative Names
Borreliella spielmanii OspC; Borreliella spielmanii; B. spielmanii OspC; B. spielmanii; OspC
neutral to slightly alkaline pH and 20 % glycerol as cryoprotective agent.
Store at -70°C or below. Aliquot to avoid repeated freezing and thawing.
The Gram-negative bacterium Borreliella spielmanii is one of the pathogens of the Borreliella burgdorferi sensu lato complex causing Lyme disease. As reflected by its name, outer surface protein C (OspC) is abundantly expressed on the bacterium's outer surface.
Borreliella spielmanii OspC; Borreliella spielmanii; B. spielmanii OspC; B. spielmanii; OspC


Have you cited DAG2666 in a publication? Let us know and earn a reward for your research.

Customer Reviews

Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket


Inter- and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation


Authors: Mongodin, Emmanuel F.; Casjens, Sherwood R.; Bruno, John F.; Xu, Yun; Drabek, Elliott Franco; Riley, David R.; Cantarel, Brandi L.; Pagan, Pedro E.; Hernandez, Yozen A.; Vargas, Levy C.; Dunn, John J.; Schutzer, Steven E.; Fraser, Claire M.; Qiu, Wei-Gang; Luft, Benjamin J.

Background: Lyme disease is caused by spirochete bacteria from the Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) species complex. To reconstruct the evolution of B. burgdorferi s.l. and identify the genomic basis of its human virulence, we compared the genomes of 23 B. burgdorferi s.l. isolates from Europe and the United States, including B. burgdorferi sensu stricto (B. burgdorferi s.s., 14 isolates), B. afzelii (2), B. garinii (2), B. "bavariensis" (1), B. spielmanii (1), B. valaisiana (1), B. bissettii (1), and B. "finlandensis" (1). Results: Robust B. burgdorferi s.s. and B. burgdorferi s.l. phylogenies were obtained using genome-wide single-nucleotide polymorphisms, despite recombination. Phylogeny-based pan-genome analysis showed that the rate of gene acquisition was higher between species than within species, suggesting adaptive speciation. Strong positive natural selection drives the sequence evolution of lipoproteins, including chromosomally-encoded genes 0102 and 0404, cp26-encoded ospC and b08, and lp54-encoded dbpA, a07, a22, a33, a53, a65. Computer simulations predicted rapid adaptive radiation of genomic groups as population size increases. Conclusions: Intra-and inter-specific pan-genome sizes of B. burgdorferi s.l. expand linearly with phylogenetic diversity. Yet gene-acquisition rates in B. burgdorferi s.l. are among the lowest in bacterial pathogens, resulting in high genome stability and few lineage-specific genes. Genome adaptation of B. burgdorferi s.l. is driven predominantly by copy-number and sequence variations of lipoprotein genes. New genomic groups are likely to emerge if the current trend of B. burgdorferi s.l. population expansion continues.

Online Inquiry

Phone: *
E-mail Address: *
Technology Interest:
Type of Organization:
Service & Products Interested: *
Project Description:

Related Products

Related Resources

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

Inquiry Basket