We have established a unique platform to develop high-affinity monoclonal antibodies in rats.
Compared with commonly used mouse antibodies, rat antibodies do not have the background cross-reaction problems in immune-detection of antigens out of a mouse background, such as a mouse antigen from a mouse animal model. However, Rat monoclonal antibodies are much more difficult to develop compared with mouse monoclonal antibodies, due to the lack of a stable fusion partner cell line for rat hybridoma generation.
Creative Diagnostics has developed a proprietary hybridoma-generation platform for efficient development of high-affinity and high-specificity rat monoclonal antibodies. Our Rat Monoclonal Antibody platform allows us to offer the most comprehensive one-stop custom antibody development services in the industry.
Features of our rat hybridoma production services:
Picomolar affinity and high specificity
Excellent results even for difficult antigens
Ability to recognize subtle changes such as post-translational modifications
Novel epitope recognition
Cross-reactive antibodies recognizing human proteins and mouse orthologs
Excellent IHC results with formalin fixed paraffin embedded tissue
Ability to generate large panels of bioactive antibodies.