Rat Monoclonal Antibody Production

We have established a unique platform to develop high-affinity monoclonal antibodies in rats.

Compared with commonly used mouse antibodies, rat antibodies do not have the background cross-reaction problems in immune-detection of antigens out of a mouse background, such as a mouse antigen from a mouse animal model. However, Rat monoclonal antibodies are much more difficult to develop compared with mouse monoclonal antibodies, due to the lack of a stable fusion partner cell line for rat hybridoma generation.

Creative Diagnostics has developed a proprietary hybridoma-generation platform for efficient development of high-affinity and high-specificity rat monoclonal antibodies. Our Rat Monoclonal Antibody platform allows us to offer the most comprehensive one-stop custom antibody development services in the industry.

Features of our rat hybridoma production services:

  1. Picomolar affinity and high specificity

  2. Excellent results even for difficult antigens

  3. Ability to recognize subtle changes such as post-translational modifications

  4. Novel epitope recognition

  5. Cross-reactive antibodies recognizing human proteins and mouse orthologs

  6. Excellent IHC results with formalin fixed paraffin embedded tissue

  7. Ability to generate large panels of bioactive antibodies.

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