Rabbit CRP reference serum (DAGA-679)

Rabbit CRP reference serum, native protein

Alternative Names
Rabbit; CRP; Serum
Batch dependent - please inquire should you have specific requirements
0.1% Sodium Azide
Frozen -20°C
Antigen Description
C-reactive protein (CRP) is aprotein found in the blood, the levels of which rise in response toinflammation (i.e. C-reactive protein is an acute-phase protein). Itsphysiological role is to bind to phosphocholine expressed on the surface ofdead or dying cells (and some types of bacteria) in order to activate thecomplement system via the C1Q complex. CRP is synthesized by the liver inresponse to factors released by fat cells (adipocytes). It is a member of thepentraxin family of proteins. It is not related to C-peptide or protein C. C-reactiveprotein was the first pattern recognition receptor (PRR) to be identified.


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In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum


Authors: Hu, Shuisheng; Lin, Yuxia; Teng, Jing; Wong, Wing-Leung; Qiu, Bin

A new electrocatalytic biosensor (MOF-74(Cu) NS-CC) based on the in situ deposition of MOF-74(Cu) nanosheet on carbon cloth via a bottom-up synthetic approach in a glass tube was developed. The electrocatalytic activity of the deposited MOF-74(Cu) NS was demonstrated in the oxidation of glucose to gluconate under alkaline conditions. The results revealed that the proposed method of in situ formation of MOF-74(Cu) NS onto a carbon cloth surface in a multi-layer solution is capable to generate a stable MOF-74(Cu) NS-CC electrode with excellent sensing performance. When the as-synthesized MOF-74(Cu) NS-CC was applied directly as the working electrode for glucose sensing, it showed much higher conductivity and redox activity than MOF-74(Cu) NS-GCE. With the potential applied at 0.55 V (vs. Ag/AgCl), this new electrocatalytic biosensor exhibits an excellent linear relationship between current density and concentration of glucose. Moreover, a wide linear range of detection (1.0 to 1000 mu M) was observed. The limit of detection was found to be 0.41 mu M (S/N = 3). The response sensitivity is 3.35 mA mM(-1) cm(-2) when the concentration of glucose is in the range 1-100 mu M and 3.81 mA mM(-1) cm(-2) for the 100-1000 mu M concentration range. This study provides a low-cost, easy to prepare, and reproducible methodology for the synthesis of highly redox-active nanomaterials based on the in situ formation of two-dimensional MOF-74(Cu) NS for the development of new electrocatalytic biosensors. Graphical abstract

TAK-242 Attenuates Crush Injury Induced Acute Kidney Injury through Inhibiting TLR4/NF-kappa B Signaling Pathways in Rats


Authors: Wang, Jinxiang; Chen, Zhiguo; Hou, Shike; Liu, Ziquan; Lv, Qi

Background: To investigate if toll-like receptor (TLR) 4/nuclear factor-kappa B (NF-kappa B) signaling pathways mediated crush injury induced acute kidney injury (AKI) in rats, and if TAK-242 (a specific inhibitor of TLR4) attenuates the injury through inhibiting the signaling pathways. Methods: This study was divided into two parts: (1) Establish the crush injury model: 50 rats were randomly divided into control group and four crush injury groups (n = 10/group). Crush injury groups were given 3kg pressure for eight hours and were sacrificed at the time points of 0h, 6h, 12h, and 24h after relieving pressure. And (2) Select the most obvious injury group (12h group) for drug intervention group. Thirty rats were randomly divided into control group, 12h group, and 12h+TAK-242 group (n = 10/group). Two parts detection were as follows: pathological changes of kidney tissues were observed in Haematoxylin and Eosin (HE) staining. Serum creatinine, blood urea nitrogen (BUN), myoglobin (Mb), and blood potassium were examined by automatic biochemical analysis instrument. Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were measured by enzyme-linked immunosorbent assay (ELISA). The TLR4 messenger ribonucleic acid (mRNA), TLR4, and P65 were detected by real-time polymerase chain reaction (PCR), western blot, immunohistochemistry staining. Results: Compared with the control group, kidney tissues were damaged in crush injury groups, and most obvious in the 12h group. The level of serum creatinine, BUN, Mb, blood potassium, IL-6, TNF-alpha, and TLR4mRNA were increased in the crush injury groups and significantly increased in the 12h group (P <.05). The TLR4 and P65 were significantly increased in the 12h group (P <.05). Compared with the 12h group, kidney tissue damage was significantly reduced in the TAK-242 group (P <.05). The level of serum creatinine, BUN, Mb, blood potassium, IL-6, TNF-alpha, TLR4mRNA, TLR4, and P65 in the TAK-242 group were significantly reduced (P <.05). Conclusion: The present findings conclude that TLR4/NF-kappa B signaling pathways mediated crush injury induced AKI in rats, and TAK-242 attenuates the injury through inhibiting the signaling pathways.

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