Human RSPO1 blocking peptide (CDBP2579)

Synthetic Human RSPO1 blocking peptide for BL

Product Overview
Blocking peptide for anti-RSPO1 antibody
Target
RSPO1
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Procedure
None
Format
Liquid
Concentration
200 μg/ml
Size
50 μg
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
UniProt ID
Antigen Description
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Function
heparin binding; protein binding; receptor binding;
Synonyms
RSPO1; R-spondin 1; R spondin homolog (Xenopus laevis); R-spondin-1; FLJ40906; RSPONDIN; R-spondin homolog; roof plate-specific spondin-1; RSPO; CRISTIN3; RP11-566C13.1;

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References


Zhao, JS; Kim, KA; et al. Tipping the balance: modulating the Wnt pathway for tissue repair. TRENDS IN BIOTECHNOLOGY 27:131-136(2009).
Wong, VSC; Oh, AH; et al. R-spondin1 deficiency in mice improves glycaemic control in association with increased beta cell mass. DIABETOLOGIA 54:1726-1734(2011).

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