The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
Function
DNA binding; androgen receptor binding; ligase activity; metal ion binding; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
Synonyms
RNF6; ring finger protein (C3H2C3 type) 6; E3 ubiquitin-protein ligase RNF6; DKFZp686P0776; RING H2 protein RNF 6; RING-H2 protein RNF-6;
Citations
Publication ()
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References
Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats
BRAIN AND BEHAVIOR
Authors: Liu, Bin; Zhang, Gang; Cui, Shukun; Du, Guoliang
Background Traumatic brain injury (TBI) has ranked as one of the leading causes of disability and death in the world. The neuroinflammation mediated by signal transducer and activator of transcription 3 (STAT3) signaling during the progression of TBI leads to long-term neurodegeneration. Ring finger protein 6 (RNF-6) is an E3 ubiquitin ligase and can regulate the activity of STAT3 signaling pathway by targeting its inhibitors. However, the mechanism underlying this process in TBI remains poorly understood. Methods In this research, cortical impact injury was used to construct the TBI rat model. Western blot assay was performed to evaluate the protein levels of RNF6, Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1), and STAT3/pSTAT3. QRT-PCR assay was performed to assess the RNA levels of RNF6 and other cytokines. The neural function of TBI rats was estimated by modified Neurological Severity Scores test. Results The expression of RNF-6 was up-regulated in the brain tissues of TBI rats. Down-regulation of RNF6 alleviated the symptoms and improved the neural recovery postinjury in TBI rats. Inhibition of RNF6 suppressed the cerebral inflammation by up-regulating the protein level of SHP-1 and down-regulating the phosphorylation level of STAT3. Conclusion Inhibition of RNF6 alleviated TBI by suppressing the STAT3 signaling in TBI rats.
RING-Finger protein 6 (Rnf6) is upregulated during prostate cancer progression and promotes prostate cancer growth via inducing atypical ubiquitylation of androgen receptor
CANCER RESEARCH
Authors: Xu, Kexin; Qiu, Yun; Shimelis, Hermela; Yang, Xi
COA
Publication 
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