Vaccine Grade

R848

  • Product Name
  • R848 / Imidazoquinoline compound
  • Cat.No.
  • ADJU-030CL
  • Content
  • 5 mg of lyophilized R848 Vaccine grade adjuvant
    10 ml sterile endotoxin-free physiological water (NaCl 0.9%)
  • Storage and Stability
  • R848 is shipped at room temperature and should be stored at 4°C or -20°C. Lyophilized product is stable 1 year when properly stored.
    - Upon resuspension, prepare aliquots of R848 and store at -20°C for long term storage. Resuspended product is stable 6 months when properly stored. Avoid repeated freeze-thaw cycles.
  • Description

  • R848 (resiquimod), a small molecular weight imidazoquinoline compound, is an immune response modifier with potent antiviral and antitumor activities. R848 is being evaluated as an adjuvant in FDA-approved clinical vaccine trials. R848 immune properties result from its ability to induce the production of pro-inflammatory cytokines through the activation of Toll-like receptor (TLR)-7 and TLR8. In vitro and in vivo studies have shown that R848 promotes the secretion of Th1 cytokines, including IFN-g, IFN-a, IL-12 and TNF-a. R848 is capable of skewing antibody responses toward a Th1 IgG2a response and away from a Th2 IgE response, a feature mediated in part by IFN-a and IL-12. Unlike most adjuvants, R848 can be administered by a different route than the antigen, suggesting that it does not produce a depot effect. Preclinical studies in mice have shown that R848 is able to promote adaptive immune responses to codelivered antigens and provide protection against live infection challenges.
  • Preparation of Sterile Stock Solution (1 mg/ml)
  • Add 5 ml endotoxin-free physiological water to the 5 mg R848 vial to obtain a solution at 1 mg/ml.
    - Mix the solution by pipetting up and down.
  • Working Concentration
  • 10-100 μg/mouse
  • Chemical Properties
  • CAS number: 144875-48-9
    Formula: C17H22N4O2, HCl
    Molecular weight: 350.8
    Solubility: 1 mg/ml in physiological water

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