Bovine Ro/SS-A (DAG616)

Bovine Ro/SS-A, natural protein Datasheet

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Product Overview
Purified Bovine Ro/SS-A protein (60 kDa) frombovine tissues by protein-chemical methods.
Nature
Native
Tag/Conjugate
Unconjugated
Purity
(purity > 60%) SDS-PAGE; Western blot with SLE sera (secondary Sj?gren'ssyndrome).
Concentration
0.2-0.6μg/ml (depending on the type of ELISA plate and coating buffer). Suitable forbiotinylation and iodination.
Buffer
Neutralto slightly alkaline pH.
Storage
2-8°C short term, -20°C long term
Introduction
TROVE2 (TROVE domain family member 2), also known as 60 kD Ro/SSA autoantigen, is an RNA binding protein that binds to several small cytoplasmic noncoding RNA molecules of unknown function known as Y RNAs. It may stabilize these RNAs from degradation. TROVE2 also binds misfolded 5S rRNA precursors suggesting it may function in a quality control pathway for ribosome biogenesis. The 60 kD Ro/SSA autoantigen is recognized by autoantibodies in certain lupus erythematosus and Sjogren syndrome.
Antigen Description
TROVE2 (TROVEdomain family member 2), also known as 60 kD Ro/SSA autoantigen, is an RNAbinding protein that binds to several small cytoplasmic noncoding RNAmolecules of unknown function known as Y RNAs. It may stabilize these RNAsfrom degradation. TROVE2 also binds misfolded 5S rRNA precursors suggestingit may function in a quality control pathway for ribosome biogenesis. The 60kD Ro/SSA autoantigen is recognized by autoantibodies in certain lupuserythematosus and Sjogren syndrome.
Keywords
TROVE2; TROVE domain family, member 21; RORNP; RO60; gastric cancer multi-drug resistance protein; SSA2; Sjoegren syndrome type A antigen; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS

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