Study on particle movement characteristics in sandblast cylinder based on PIV technolo
POLISH JOURNAL OF CHEMICAL TECHNOLOGY
Authors: Hui, Zhiquan; Wu, Feng; Duan, Haojie; Yang, Bo; Lin, Jinmei; Wang, Lian; Huang, Si
PIV technology was used to investigate the influence of the particles' relevant parameters on the instantaneous movement characteristics in the sandblast cylinder under the circumstance of different particle sizes, different section heights and different stacking conditions. As the diameter increased, particles had a greater velocity and energy when approaching the wall, which would cause a serious abrasion. The influence of test selection factors on the particles' radial velocity of particles was greater than that on axial velocity. The radial velocity and axial velocity on the surface of the cylindrical section were all reduced to a lower level when the particles approach the tank wall. When r > 03 R, the particle velocity maintained at a higher level, but then decreased slowly when r > 0.7 R. Therefore, the abrasion of the conical section of the sandblast cylinder when r > 03 R should be paid more attention to.
Flow, suspension, and mixing dynamics inDASGIPbioreactors: Part 1
Authors: Samaras, Jasmin J.; Micheletti, Martina; Ducci, Andrea
The bioreactor flow environment has a significant impact on process performance, especially in stem cell cultures. The work of Correia et al found intermittent agitation modes to improve induced pluripotent stem cell (iPSC)-cardiomyocyte differentiation yields; however, to date, the impact within the flow has not been fully characterized. This work aims to characterize the flow dynamics occurring within a commercially available DASGIP bioreactor, equipped with a two-blade paddle impeller, operating under different agitation modes and for two bottom geometries. The paddle impeller configuration generated an axial flow profile due to a large impellerD/Tand blade confinement with the bioreactor wall. The application of intermittent agitation was shown to induce two transient spikes in flow velocity and shear stress, the amplification of which increased with dwell duration. Marginally increasing the dwell duration was shown previously to increase differentiation yields, therefore it can be stipulated that introduction of these spikes was favorable toward cardiogenic differentiation.