Human Proteinase 3 (DAG4872)

Human Proteinase 3, natural protein Datasheet

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Product Overview
Native human Proteinase 3
Nature
Native
Tag/Conjugate
Unconjugated
Purity
SDS-PAGE; capillary electrophoresis (purity > 80% in the sum of different glycosylation isoforms according to following section); Western blot with rabbit anti-PR3 antisera and mouse anti-PR3 monoclonal antibodies.
Concentration
0.5-1.0 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
Storage
2-8°C short term, -20°C long term
Antigen Description
Proteinase 3 (PR3) is a neutral serine protease stored in the azurophilic neutrophilic granulocytes, consisting of 228 amino acids (MW 29-33 kDa depending on glycoform). It has substantial sequence homology with neutrophil elastase, cathepsin G and azurocidin. The primary function of these neutrophil-derived serine proteases is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body
Keywords
coagulation factor II (thrombin) receptor-like 2; 3539; Ensembl:ENSG00000164220; FLJ51933; proteinase-activated receptor 3; thrombin receptor-like 2; protease-activated receptor 3; proteinase-activated receptor-3; Coagulation factor II receptor-like 2 (pr

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