Human PICALM blocking peptide

Product Overview

Blocking peptide for anti-PICALM antibody

Target

PICALM

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.

Format

Liquid

Concentration

200 μg/ml

Buffer

PBS containing 0.02% sodium azide

Preservative

0.02% Sodium Azide

Storage

Store at -20℃, stable for one year.

Gene ID

8301

UniProt ID

Q13492

Antigen Description

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Function

1-phosphatidylinositol binding; clathrin adaptor activity; clathrin binding; clathrin binding; clathrin binding; clathrin heavy chain binding; protein binding;

Synonyms

PICALM; phosphatidylinositol binding clathrin assembly protein; LAP; CALM; CLTH; phosphatidylinositol-binding clathrin assembly protein; clathrin assembly lymphoid myeloid leukemia protein;