Human PCSK6 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-PCSK6 antibody

Target

PCSK6

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

Function

endopeptidase activity; heparin binding; nerve growth factor binding; serine-type endopeptidase activity;

Synonyms

PCSK6; proprotein convertase subtilisin/kexin type 6; SPC4; PACE4; subtilisin/kexin-like protease PACE4; subtilisin-like proprotein convertase 4; paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4;