Anti-PCNP monoclonal antibody (CABT-BL2863)


Host Species
Antibody Isotype
Species Reactivity
Recombinant fragment derived from internal sequence of human PCNP


Alternative Names
PCNP; PEST proteolytic signal containing nuclear protein; PEST proteolytic signal-containing nuclear protein; Ab2 416; AI647035; DKFZp781I24156
Entrez Gene ID
UniProt ID


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Taxonomic Distinctness of the subterranean fauna from Peruacu Caves National Park, state of Minas Gerais, eastern Brazil


Authors: Oliveira Monte, Bruno Gabriel; Bichuette, Maria Elina

Limiting factors of subterranean environments, high relative air humidity and, especially, permanent darkness, represent ecological filters for organisms and biodiversity patterns of surface and subterranean communities display wide disparities. Subterranean diversity and singularity are, thus, better expressed when the common presence of rare and endemic species are considered. Our study aimed to describe the diversity of the cave fauna from 14 caves from Peruacu Caves National Park (PCNP), eastern Brazil. We analyzed the regional diversity using the index that includes the average taxonomic distinction (TD - Delta +,AvTD). We recorded 1,674 individuals belonging to 10 Classes and 237 morphotypes, 11 troglobitic and two troglomorphic and possible troglobites. Greatest species abundance (N=330) and richness (s=76) were recorded at Lapa do Cipo cave, followed by Gruta Olhos d'Agua (N=330, s=71), which shows the highest TD value (Delta+ = 90.18) in relation to the others, including the richest Lapa do Cipo (Delta+ = 85.24), consequence of the several taxonomic units with large number of species. The below-expected values of TD (Delta+ = 87.70) may indicate anthropic impacts on these communities. Our results demonstrate that Gruta Olhos d' Agua and Lapa do Cipo caves are the most important sites for the occurrence of endemic and troglobitic species and may be part of a complex system that should be considered for a more efficient conservation planning.

Versatile Coordination and C-C Coupling of Diphosphine-Tethered Imine Ligands with Ni(II) and Ni(0)


Authors: Verhoeven, Dide G. A.; Negenman, Hidde A.; Orsino, Alessio F.; Lutz, Martin; Moret, Marc-Etienne

Ligands that can adapt their coordination mode to the electronic properties of a metal center are of interest to support catalysis or small molecule activation processes. In this context, the ability of imine moieties to bind in either an eta(1)(N)-fashion via sigma-donation of the lone pair or, less commonly, in an eta(2)(C,N)-fashion via pi-coordination is potentially attractive for the design of new metal-ligand cooperative systems. Herein, the coordination chemistry of chelating ligands with a diphosphine imine framework (PCNP) to nickel is investigated. The imine moiety binds in an eta(1)(N)-fashion in a Ni(II)Cl-2 complex. The uncommon eta(2)(C,N)-interaction is obtained in Ni(0) complexes in the presence of a PPh3 coligand. Increasing the bulk on the phosphine side-arms in the Ni(0) complexes, by substituting phenyl for o-tolyl groups, leads to a distinct binding mode in which only one of the phosphorus atoms is coordinated. In the absence of a coligand, a mixture of two different dimeric Ni(0) complexes is formed. In one of them, the imine adopts an uncommon eta(1)(N)eta(2)(C,N) bridging mode of the ligand to nickel, while the second one may involve reactivity on the ligand by the formation of a new C-C bond by oxidative coupling. The latter is supported by the isolation and structural characterization of a crystalline bis-CO derivative featuring a C-C bond formed by oxidative coupling of two imine moieties.

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