The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements.
Function
protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
Synonyms
CREB3L1; cAMP responsive element binding protein 3-like 1; cyclic AMP-responsive element-binding protein 3-like protein 1; BBF 2 homolog (drosophila); OASIS; BBF-2 homolog; old astrocyte specifically induced substance; old astrocyte specifically-induced substance; cAMP-responsive element-binding protein 3-like protein 1;
Citations
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