Human Nup62 [His], recombinant protein from Baculovirus
Recombinant human Nup62, his-tagged
SDS-PAGE (purity > 80%); Western-blot with i: pol yclonal anti-Nup62 antibodies; ii: monoclonal anti-hexa-His-tag antibody.
0.5-1.0 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
Primary biliary cirrhosis (PBC) is an autoimmune chronic cholestatic liver disease characterized by destruction of intrahepatic bile ducts and development of cirrhosis and liver failure. Serologically, PBC is characterized by the presence of antimitochondrial (AMA, M2) antibodies. The immunological profile of PBC also includes antinuclear antibodies (ANA), presenting two distinct patterns, multiple nuclear dots (MND) and rim-like/membranous patterns in IIF. Sp100 and promyelocytic leukemia antigen account for the MND pattern, and gp210, nucleoporin p62 and lamin B receptor are associated with nuclear membrane staining
NUP62; nucleoporin 62kDa; nucleoporin 62kD; nuclear pore glycoprotein p62; DKFZp547L134; FLJ20822; FLJ43869; IBSN; MGC841; p62; SNDI; nucleoporin Nup62; 62 kDa nucleoporin;