NPHS1 blocking peptide (CDBP5847)

Synthetic NPHS1 blocking peptide for IB Datasheet

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Nature
Synthetic
Immunogen
16 amino acids near the center of human Nephrin.
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Format
Liquid
Concentration
200 μg/mL
Size
0.05mg
Storage
-20°C
UniProt ID
Antigen Description
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.[provided by RefSeq, Oct 2009]
Function
alpha-actinin binding; myosin binding; protein binding; protein domain specific binding; spectrin binding
Synonyms
NPHS1; nephrosis 1, congenital, Finnish type (nephrin); CNF; NPHN; nephrin; renal glomerulus-specific cell adhesion receptor

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