HCV Nonstructural Protein 4A, B (aa 1658 - 1863) [Rhodamine], recombinant protein from E. coli
Recombinant Hepatitis C Virus NS4 a+b (a.a. 1658-1863), Rhodamine-Conjugated
Immunoreactive with sera of HCV-infected individuals
Protein is > 95% pure as determined by 10% PAGE (coomassie staining).
20 mM Tris-Hcl, pH 8 + 8 M urea and 10 mM B-ME.
2-8°C short term, -20°C long term
HCV is a positive, single-stranded RNAvirus in the Flaviviridae family. The genome is approximately 10, 000nucleotides and encodes a single polyprotein of about 3, 000 amino acids.HCVis responsible for a large proportion of worldwide chronic viral hepatitides.Most of these infections develop into chronic hepatitis, which oftenprogresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis Cinfection.The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is arelatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the N
HCV; HCV NS4; Hepatitis C Virus nonstructural antigen 4; Non structural protein 4A; Non structural protein 4B; NS4A; NS4B; Flaviviridae; Hepacivirus; Hepatitis C virus; p27; p8; Hepatitis C Virus NS4; HCV NS4 Genotype 5; Hepatitis C Virus NS4 Genotype 5