HCV Nonstructural Protein 4A, B [Rhodamine] (DAG3498)

HCV Nonstructural Protein 4A, B (aa 1658 - 1863) [Rhodamine], recombinant protein from E. coli Datasheet

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Product Overview
Recombinant Hepatitis C Virus NS4 a+b (a.a. 1658-1863), Rhodamine-Conjugated
Specificity
Immunoreactive with sera of HCV-infected individuals
Nature
Recombinant
Tag/Conjugate
Rhodamine
Purity
Protein is > 95% pure as determined by 10% PAGE (coomassie staining).
Preservative
20 mM Tris-Hcl, pH 8 + 8 M urea and 10 mM B-ME.
Storage
2-8°C short term, -20°C long term
Introduction
HCV is a positive, single-stranded RNAvirus in the Flaviviridae family. The genome is approximately 10, 000nucleotides and encodes a single polyprotein of about 3, 000 amino acids.HCVis responsible for a large proportion of worldwide chronic viral hepatitides.Most of these infections develop into chronic hepatitis, which oftenprogresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis Cinfection.The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is arelatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
Antigen Description
NS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the N
Keywords
HCV; HCV NS4; Hepatitis C Virus nonstructural antigen 4; Non structural protein 4A; Non structural protein 4B; NS4A; NS4B; Flaviviridae; Hepacivirus; Hepatitis C virus; p27; p8; Hepatitis C Virus NS4; HCV NS4 Genotype 5; Hepatitis C Virus NS4 Genotype 5

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