HCV Nonstructural Protein 4 (aa 1658 - 1863) [Biotin], recombinant protein from E. coli
Recombinant Hepatitis C Virus NS4 a+b (a.a. 1658-1863), Biotin-Conjugated
Immunoreactive with sera of HCV-infected individuals.
HCV NS4 a+b Biotin protein is > 95% pure as determined by 10% PAGE (coomassie staining).
20 mM Tris-Hcl pH 8 + 8 M urea + 10 mM B-ME.
2-8°C short term, -20°C long term
HCV is a positive, single-stranded RNAvirus in the Flaviviridae family. The genome is approximately 10, 000nucleotides and encodes a single polyprotein of about 3, 000 amino acids.HCVis responsible for a large proportion of worldwide chronic viral hepatitides.Most of these infections develop into chronic hepatitis, which oftenprogresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis Cinfection.The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is arelatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
HCV is a small 50 nm, enveloped, single-stranded, positive sense RNA virus in the family Flaviviridae. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by
HCV; HCV NS4; Hepatitis C Virus nonstructural antigen 4; Non structural protein 4A; Non structural protein 4B; NS4A; NS4B; Flaviviridae; Hepacivirus; Hepatitis C virus; p27; p8; Hepatitis C Virus NS4; HCV NS4 Genotype 5; Hepatitis C Virus NS4 Genotype 5