Human NFKB1 blocking peptide

Product Overview

NFkB1 peptide (N-term)

Target

NFkB p50

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

Sequence: AED DPY LGR PEQ MF

Format

Liquid

Concentration

1 mg/ml

Buffer

Antiserum containing 0.01% sodium azide

Preservative

0.01% Sodium Azide

Storage

Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.

Gene ID

4790

UniProt ID

P19838

Antigen Description

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Function

double-stranded DNA binding; heat shock protein binding; nucleic acid binding transcription factor activity; protein binding; protein homodimerization activity; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; tr

Synonyms

NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B; nuclear factor NF-kappa-B p105 subunit; NF-kappabeta; DNA binding factor KBF1; DNA-binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit;