Human NLRP8 blocking peptide

Product Overview

Blocking peptide for anti-NALP8 antibody

Target

NALP8

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.

Format

Liquid

Concentration

200 μg/ml

Buffer

PBS containing 0.02% sodium azide

Preservative

0.02% Sodium Azide

Storage

Store at -20℃, stable for one year.

Gene ID

126205

UniProt ID

Q86W28

Antigen Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Function

ATP binding; molecular_function;

Synonyms

NLRP8; NLR family, pyrin domain containing 8; PAN4; NALP8; NOD16; CLR19.2; NACHT, LRR and PYD domains-containing protein 8; PYRIN and NACHT-containing protein 4; NACHT, LRR and PYD containing protein 8; NACHT, leucine rich repeat and PYD containing 8; nucleotide-binding oligomerization domain protein 16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8;