M. tuberculosis HSP65 (DAG-P2842)

M. tuberculosis HSP65 (full length), recombinant protein from E. coli Datasheet

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Product Overview
Mycobacterium tuberculosis Ag85B full length protein
Nature
Recombinant
Tag/Conjugate
Unconjugated
Purity
> 90 % by SDS-PAGE.Purity:Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Format
Lyophilised
Buffer
Preservative: None No additives
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: None No additives
Reconstitution
Reconstitute in sterile 18MOhm/cm water at not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Introduction
Mycobacterium tuberculosis (MTB) is a pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of most cases of tuberculosis (TB). First discovered in 1882 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell
Antigen Description
Mycobacterium tuberculosis is the most common cause of tuberculosis. Primary infection begins with inhalation of 1 to 10 aerosolised bacilli. The pathogenicity of the organism is determined by its ability to escape host immune responses as well as eliciting delayed hypersensitivity. Alveolar macrophages engulf the invading cells but are unable to mount an effective defense. Several virulence factors are responsible for this apparent failure; most notably in the mycobacterial cell wall are the cord factor, lipoarabinomannan, and the 65 kd heat shock protein or HSP65. The emergence of new strains of resistant Mycobacterium tuberculosis has created new interest in clinical diagnosis. Studies have shown immunohistochemical techniques to be superior to conventional special stains. Thus the demonstration of mycobacterial antigens are not only useful in establishing mycobacterial aetiology, but can also be used as an alternative method to the conventional Ziehl-Neelsen method.
Keywords
60 kDa chaperonin 2; 65 kDa antigen; Antigen A; Cell wall protein A; groEL; GroEL 2; GroEL protein 2; GroEL2; GroL2; Heat shock protein 65; Hsp65; M. tuberculosis cell wall protein A; M. tuberculosis heat shock protein 65; M. tuberculosis Hsp 65; M. tuber

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