Anti-PRG4 monoclonal antibody (CABT-21518MH)

Mouse anti-Human PRG4 monoclonal antibody for IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3B7
Species Reactivity
Human
Immunogen
PRG4 (NP_005798, 1305 a.a. ~ 1405 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
proteoglycan 4; CACP; MSF; proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zoneprotein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome); SZP; OTTHUMP00000033580
Entrez Gene ID

Product Background


Gene summary
PRG4 (Proteoglycan 4) is a Protein Coding gene. Diseases associated with PRG4 include camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Among its related pathways are ERK Signaling and Integrin Pathway. GO annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is ENSG00000273171. The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants.
Antigen Description
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
Mouse monoclonal antibody raised against a partial recombinant PRG4. Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) [MIM:208250]: An autosomal recessive disorder characterized by the association of congenital or early-onset camptodactyly and non-inflammatory arthropathy with synovial hyperplasia. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure, non-inflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. Some patients also manifest progressive coxa vara deformity and/or non-inflammatory pericardial or pleural effusions. Note=The disease is caused by mutations affecting the gene represented in this entry. Proteoglycan 4 or lubricin is a proteoglycan that in humans is encoded by the PRG4 gene. This proteoglycan acts as a joint/boundary lubricant. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature). The expression of lubricin has also been detected and the protein localized in tendon, meniscus, lung, liver, heart, bone, ligament, muscle, and skin. The function about PRG4 antigen include polysaccharide binding; protein binding; scavenger receptor activity.

Citations


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References


Rhee, DK; Marcelino, J; et al. Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing. JOURNAL OF BIOLOGICAL CHEMISTRY 280:31325-31332(2005).
Rees, SG; Davies, JR; et al. Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. MATRIX BIOLOGY 21:593-602(2002).

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